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Arbidol

Cat. No. 7235 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
化学名： Ethyl 6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Arbidol

Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC50 = 4.11 μM).

化合物库 for Arbidol

Arbidol is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Arbidol

分子量 513.88
公式 C22H25BrN2O3S.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 131707-23-8
PubChem ID 9958103
InChI Key OMZHXQXQJGCSKN-UHFFFAOYSA-N
Smiles Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Arbidol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 51.39 100
DMSO 51.39 100

制备储备液 for Arbidol

以下数据基于产品分子量 513.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.73 mL 19.46 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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参考文献 for Arbidol

参考文献是支持产品生物活性的出版物。

Boriskin et al (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr.Med.Chem. 15 997 PMID: 18393857

Wang et al (2020) The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 6 28 PMID: 32373347

If you know of a relevant reference for Arbidol, please let us know.

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关键词: Arbidol, Arbidol supplier, Umifenovir, influenza, viral, inhibitor, hemagglutinins, antiviral, respiratory, infection, sars-cov-2, covid-19, COVID-19, Non-selective, Antivirals, Coronavirus, 7235, Tocris Bioscience

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