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Submit Review[Arg8]-Vasopressin
说明： Antidiuretic hormone
别名： AVP
纯度： ≥95% (HPLC)
生物活性 for [Arg8]-Vasopressin
[Arg8]-Vasopressin is an antidiuretic hormone found in most mammalian species. Also acts as a neurotransmitter at synapses in the brain; increases [Ca2+]i in cultured rat hippocampal neurons.
技术数据 for [Arg8]-Vasopressin
| 分子量 | 1084.23 |
| 公式 | C46H65N15O12S2 |
| 序列 |
CYFQNCPRG (Modifications: Disulfide bridge: 1-6, Gly-9 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 113-79-1 |
| PubChem ID | 90488786 |
| InChI Key | KBZOIRJILGZLEJ-MCRCNMGXSA-N |
| Smiles | N[C@@H]1CSSC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for [Arg8]-Vasopressin
| 溶解性 | Soluble to 0.50 mg/ml in water |
产品说明书 for [Arg8]-Vasopressin
参考文献 for [Arg8]-Vasopressin
参考文献是支持产品生物活性的出版物。
Migara et al (1999) [Arg8]-vasopressin-induced increase in intracellular Ca2+ concentration in cultutred rat hippocampal neurons. Brain Res.Bull. 49 343 PMID: 10452354
Chan et al (2000) Discovery and design of novel and selective vasopressin and oxyt. agonists and antagonists: the role of bioassays. Exp.Physiol. 85S 7S
Cowley et al (2000) Control of renal medulaary circulation by vasopressin V1 and V2 receptors in the rat. Exp.Physiol. 85S 223S
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关键词: [Arg8]-Vasopressin, [Arg8]-Vasopressin supplier, Antidiuretic, hormone, V2, Receptors, V1, Vasopressin, AVP, 2935, Tocris Bioscience
2 篇 [Arg8]-Vasopressin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [Arg8]-Vasopressin 的部分引用包括：
Leroy et al (2018) A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature 564 213 PMID: 30518859
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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The role of protein kinases C (PKC) and B (PKB) mediating VP induced antiapoptosis in H32 cells was investigated.
By
Anonymous on 02/19/2019
种属： Human
细胞系/组织： H32
To determine the signaling pathways mediating the effect of V1 vasopressin VP, cells were incubated in the presence and absence of inhibitors.The role of protein kinases C (PKC) and B (PKB) mediating VP induced antiapoptosis in H32 cells was investigated.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.