ARL 17477 dihydrochloride

Cat. No. 3319 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective nNOS inhibitor

化学名： N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ARL 17477 dihydrochloride

ARL 17477 dihydrochloride is a selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC₅₀ values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

化合物库 for ARL 17477 dihydrochloride

ARL 17477 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ARL 17477 dihydrochloride

分子量	442.83
公式	C₂₀H₂₀ClN₃S.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	866914-87-6
PubChem ID	9824646
InChI Key	SOXBYIKSUDXMIE-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARL 17477 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	22.14	50
	DMSO	44.28	100

制备储备液 for ARL 17477 dihydrochloride

以下数据基于产品分子量 442.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for ARL 17477 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ARL 17477 dihydrochloride

参考文献是支持产品生物活性的出版物。

Hicks et al (1999) Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 381 113 PMID: 10554878

O'Neill et al (2000) ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 871 234 PMID: 10899290

Zhang et al (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 16 599 PMID: 8964798

If you know of a relevant reference for ARL 17477 dihydrochloride, please let us know.

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关键词: ARL 17477 dihydrochloride, ARL 17477 dihydrochloride supplier, neuronal, nitric, oxide, synthase, nNOS, inhibitors, inhibits, ARL17477, 3319, Tocris Bioscience

1 篇 ARL 17477 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ARL 17477 dihydrochloride 的部分引用包括：

Grekov et al (2017) Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase. Biomed Res Int 2017 1309485 PMID: 29181385

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