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ARN 14494

Cat. No. 7134 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent serine palmitoyltransferase inhibitor
化学名： rel-1-[1-[2-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ARN 14494

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

技术数据 for ARN 14494

分子量 424.55
公式 C24H32N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1037834-43-7
PubChem ID 24857490
InChI Key TYZOOEYUTZDYPB-HDICACEKSA-N
Smiles [H][C@@]12CCC[C@@]1(CN(C(CN3CCC(N4C(CC5=CC(C(NC)=O)=CC=C45)=O)CC3)=O)C2)[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARN 14494

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.12 5
ethanol 21.23 50

制备储备液 for ARN 14494

以下数据基于产品分子量 424.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.71 mL 23.55 mL 47.11 mL
2.5 mM 0.94 mL 4.71 mL 9.42 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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参考文献 for ARN 14494

参考文献是支持产品生物活性的出版物。

De Vita et al (2019) Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury. ACS Chem.Neurosci. 10 1627 PMID: 30481470

If you know of a relevant reference for ARN 14494, please let us know.

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关键词: ARN 14494, ARN 14494 supplier, ARN14494, serine, palmitoyltransferase, inhibitors, inhibits, potent, Alzheimer, disease, ceramides, Other, Transferases, 7134, Tocris Bioscience

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