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说明： FAAH-like anandamide transporter (FLAT) inhibitor
化学名： 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide
纯度： ≥98% (HPLC)
生物活性 for ARN 272
FAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.
技术数据 for ARN 272
| 分子量 | 432.47 |
| 公式 | C27H20N4O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 488793-85-7 |
| PubChem ID | 24802717 |
| InChI Key | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ARN 272
参考文献 for ARN 272
参考文献是支持产品生物活性的出版物。
Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356 PMID: 22860203
Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64 PMID: 22101642
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关键词: ARN 272, ARN 272 supplier, ARN272, FAAH, like, anandamide, transporters, FLAT, inhibitors, inhibits, cytosolic, variant, FAAH1, nociceptive, inflammatory, pain, analgesics, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4574, Tocris Bioscience
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