Fatty Acid Amide Hydrolase
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.
Fatty Acid Amide Hydrolase Inhibitors |
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|---|---|
| Cat. No. | 产品名称/活性 |
| 1462 | AACOCF3 |
| FAAH inhibitor | |
| 4715 | JZL 195 |
| Dual FAAH and MAGL inhibitor | |
| 6374 | PF 04457845 |
| Potent and selective irreversible FAAH inhibitor | |
| 4175 | PF 3845 |
| Selective FAAH inhibitor | |
| 5209 | TAK 21d |
| Potent FAAH inhibitor | |
| 4355 | TC-F 2 |
| Potent, reversible and selective FAAH inhibitor | |
| 4612 | URB 597 |
| Potent and selective FAAH inhibitor | |
Substrates |
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| Cat. No. | 产品名称/活性 |
| 0879 | Palmitoylethanolamide |
| FAAH and PAA substrate. Selective GPR55 agonist | |
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine.
FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.
External sources of pharmacological information for Fatty Acid Amide Hydrolase :
Literature for Fatty Acid Amide Hydrolase
Tocris offers the following scientific literature for Fatty Acid Amide Hydrolase to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
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