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ARN 726

Cat. No. 5861 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5861 has been discontinued.

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说明： Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
化学名： 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for ARN 726

ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.

技术数据 for ARN 726

分子量 268.35
公式 C14H24N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1628343-77-0
PubChem ID 78319072
InChI Key FNLUJRBWJBUJTC-LBPRGKRZSA-N
Smiles O=C(OCCCCC1CCCCC1)N[C@H]2CNC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ARN 726

参考文献是支持产品生物活性的出版物。

Ribeiro et al (2015) A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 10 1838 PMID: 25874594

Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511

Bonezzi et al (2016) An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 356 656 PMID: 26769918

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关键词: ARN 726, ARN 726 supplier, ARN726, NAAA, N-acylethanolamine, acid, amidase, potent, inhibitors, inhibits, anti, inflammatory, activity, based, protein, profiling, probe, ABPP, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5861, Tocris Bioscience

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