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说明： Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist
化学名： N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
纯度： ≥98% (HPLC)
生物活性 for Arvanil
Arvanil is a cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist (Ki values are 0.5 and 0.3 μM respectively). Also inhibits the anandamide transporter (IC50 = 3.6 μM). Analgesic, vasodilatory and anti-inflammatory in vivo.
技术数据 for Arvanil
| 分子量 | 439.64 |
| 公式 | C28H41NO3 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 128007-31-8 |
| PubChem ID | 6449767 |
| InChI Key | QVLMCRFQGHWOPM-ZKWNWVNESA-N |
| Smiles | O=C(NCC1=CC=C(O)C(OC)=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Arvanil
参考文献 for Arvanil
参考文献是支持产品生物活性的出版物。
Di Marzo et al (2000) Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. Eur.J.Pharmacol. 406 363 PMID: 11040343
Melck et al (1999) Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors. Biochem.Biophys.Res.Commun. 262 275 PMID: 10448105
Szallasi and Di Marzo (2000) New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 23 491 PMID: 11006466
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关键词: Arvanil, Arvanil supplier, Potent, CB1, TRPV1, VR1, agonists, anandamide, transporters, inhibitors, inhibits, AMT, Cannabinoids, Monoamine, Neurotransmitter, Receptors, Vanillioid, TRPV, TRP, Channels, Transient, Receptor, Potential, cb1r, Cannabinoid, Transporters, 1354, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.