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AS 1269574

Cat. No. 4177 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4177 has been discontinued.

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说明： GPR119 receptor agonist
化学名： 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for AS 1269574

AS 1269574 is a GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.

技术数据 for AS 1269574

分子量 308.17
公式 C13H14BrN3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 330981-72-1
PubChem ID 5332859
InChI Key DUKPGOOUJNUIOI-UHFFFAOYSA-N
Smiles BrC(C=C2)=CC=C2C1=NC(NCCO)=CC(C)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for AS 1269574

参考文献是支持产品生物活性的出版物。

Yoshida et al (2010) Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated Ins secretion. Biochem.Biophys.Res.Commun. 400 437 PMID: 20804735

Chepurny et al (2013) Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 27 1267 PMID: 23798572

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关键词: AS 1269574, AS 1269574 supplier, AS1269574, Supplier, GPR119, agonist, glucose-dependent, insulin, 4177, Tocris Bioscience

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