AS 1949490

Cat. No. 3718 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

化学名： 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide

纯度： ≥99% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AS 1949490

AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC₅₀ values are 0.34 μM and 0.62 μM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo.

化合物库 for AS 1949490

AS 1949490 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AS 1949490

分子量	371.88
公式	C₂₀H₁₈ClNO₂S
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1203680-76-5
PubChem ID	44473434
InChI Key	RFZPGNRLOKVZJY-AWEZNQCLSA-N
Smiles	ClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AS 1949490

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	37.19	100
	ethanol	37.19	100

制备储备液 for AS 1949490

以下数据基于产品分子量 371.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for AS 1949490

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AS 1949490

参考文献是支持产品生物活性的出版物。

Suwa et al (2010) Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur.J.Pharmacol. 642 177 PMID: 20558154

Suwa et al (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br.J.Pharmcol. 158 879 PMID: 19694723

Tsuneki et al (2019) AS1949490, an inhibitor of 5'-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons. Eur.J.Pharmacol. 851 69 PMID: 30753865

If you know of a relevant reference for AS 1949490, please let us know.

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