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Submit ReviewAS 2031477
说明： Selective FFA1 (GPR40) agonist
化学名： 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid
纯度： ≥98% (HPLC)
生物活性 for AS 2031477
AS 2034178 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.
技术数据 for AS 2031477
| 分子量 | 448.53 |
| 公式 | C27H29FN2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1030846-42-4 |
| PubChem ID | 24808572 |
| InChI Key | VENOXIKBBUVHRY-UHFFFAOYSA-N |
| Smiles | FC1=C(CCC(O)=O)C=CC(NCC2=C(CCCN3CCOC4=CC=CC=C4)C3=CC=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AS 2031477
参考文献 for AS 2031477
参考文献是支持产品生物活性的出版物。
Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent Ins secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170
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关键词: AS 2031477, AS 2031477 supplier, AS, 2031477, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Free, Fatty, Acid, Receptors, 5035, Tocris Bioscience
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