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Ascomycin

Cat. No. 4210 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4210 has been discontinued.

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说明： Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
别名： FK 520,FR 900520
化学名： (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Ascomycin

Ascomycin is a analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.

技术数据 for Ascomycin

分子量 792.01
公式 C43H69NO12
储存 Store at -20°C
CAS Number 104987-12-4
PubChem ID 5282071
InChI Key ZDQSOHOQTUFQEM-NURRSENYSA-N
Smiles O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ascomycin

参考文献是支持产品生物活性的出版物。

Motamedi et al (1996) Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J.Bacteriol. 178 5243 PMID: 8752344

Arndt et al (1999) Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 145 1989 PMID: 10463165

Revill et al (2002) Genetically engineered analogs of ascomycin for nerve regeneration. J.Pharmacol.Exp.Ther. 302 1278 PMID: 12183690

Hatanaka et al (1988) FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics. J.Antibiot (Tokyo). 41 1593

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关键词: Ascomycin, Ascomycin supplier, FK520, FR900520, Ascomycin, calcineurin, phosphatase, inhibitors, inhibits, analogs, FK, 506, fkbp12, immunosuppressives, antifungals, antibiotics, 520, FR, 900520, Protein, Ser/Thr, Phosphatases, Antibiotics, NFAT, 4210, Tocris Bioscience

篇 Ascomycin 的引用文献

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The immunosuppressant activity of Ascomycin was studied.
By Anonymous on 12/15/2019
种属： Human

The immunosuppressant activity of Ascomycin was studied. Analysis of the proteins in iMK1208 against Streptomyces species conducted.

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