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Submit ReviewAsenapine maleate
说明： Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
化学名： (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
纯度： ≥98% (HPLC)
生物活性 for Asenapine maleate
Asenapine maleate is a novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.
化合物库 for Asenapine maleate
Asenapine maleate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Asenapine maleate
| 分子量 | 401.84 |
| 公式 | C17H16ClNO.C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 85650-56-2 |
| PubChem ID | 73416848 |
| InChI Key | QGBIWSABMNWWNB-FGYPTBLJSA-N |
| Smiles | CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Asenapine maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.18 | 100 | |
| ethanol | 20.09 | 50 |
制备储备液 for Asenapine maleate
以下数据基于产品分子量 401.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for Asenapine maleate
参考文献 for Asenapine maleate
参考文献是支持产品生物活性的出版物。
Shahid et al (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 23 65 PMID: 18308814
Meltzer et al (2009) Asenapine. Nat.Rev.Drug Discov. 8 843 PMID: 19876039
Marston et al (2009) Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 206 699 PMID: 19462162
If you know of a relevant reference for Asenapine maleate, please let us know.
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关键词: Asenapine maleate, Asenapine maleate supplier, antipsychotics, 5-HT, serotonin, receptors, dopamine, alpha-adrenoceptors, a-adrenoceptors, α-adrenoceptors, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, Non-selective, Dopamine, Adrenergic, Alpha, Receptors, 3737, Tocris Bioscience
1 篇 Asenapine maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Asenapine maleate 的部分引用包括：
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.