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说明： L-PGDS inhibitor
化学名： 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
纯度： ≥98% (HPLC)
生物活性 for AT 56
AT 56 is an orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
化合物库 for AT 56
AT 56 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AT 56
| 分子量 | 397.52 |
| 公式 | C25H27N5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 162640-98-4 |
| PubChem ID | 11741525 |
| InChI Key | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
| Smiles | C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AT 56
参考文献 for AT 56
参考文献是支持产品生物活性的出版物。
Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623 PMID: 19131342
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关键词: AT 56, AT 56 supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Other, Synthases/Synthetases, 3531, Tocris Bioscience
2 篇 AT 56 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AT 56 的部分引用包括：
Rhian M et al (2015) Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase. Hypertension 66 149-57 PMID: 25966493
Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476 PMID: 26101153
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