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Atipamezole hydrochloride

Cat. No. 2937 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective α2 antagonist
化学名： 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Atipamezole hydrochloride

Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.

化合物库 for Atipamezole hydrochloride

Atipamezole hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Atipamezole hydrochloride

分子量 248.75
公式 C14H16N2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 104075-48-1
PubChem ID 13649426
InChI Key PCCVCJAQMHDWJY-UHFFFAOYSA-N
Smiles CCC2(C3=CN=CN3)CC1=CC=CC=C1C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Atipamezole hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 24.87 100
DMSO 24.87 100

制备储备液 for Atipamezole hydrochloride

以下数据基于产品分子量 248.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.02 mL 20.1 mL 40.2 mL
5 mM 0.8 mL 4.02 mL 8.04 mL
10 mM 0.4 mL 2.01 mL 4.02 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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产品说明书 for Atipamezole hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Atipamezole hydrochloride

参考文献是支持产品生物活性的出版物。

Virtanen et al (1989) Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 297 190 PMID: 2567152

Puurunen et al (2001) An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 40 597 PMID: 11249969

Jurgens et al (2007) α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 71 1572 PMID: 17341653

If you know of a relevant reference for Atipamezole hydrochloride, please let us know.

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关键词: Atipamezole hydrochloride, Atipamezole hydrochloride supplier, selective, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, receptors, alpha-adrenoceptors, a-adrenoceptors, αadrenoceptors, Adrenergic, Alpha-2, Receptors, 2937, Tocris Bioscience

2 篇 Atipamezole hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Atipamezole hydrochloride 的部分引用包括：

Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Gastroenterology 154 1680 PMID: 23707289

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

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Atipamezole hydrochloride 的评论

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behavioral pharmacology in rats.
By Corinne Kiessling on 01/04/2018
分析类型： In Vivo
种属： Rat

Behavioral neuropharmacology. Atimpamezole (0.1-1.0 mg/mL) was dissolved in 50-100% DMSO and was injected systemically in rats. Atipamezole is highly selective for the alpha2- noradrenergic receptor, and was used as a reference compound during behaviral testing.

This comes out of solution easily, even with sonicating. After fully dissolving in DMSO, add water slowly and continue to vortex or sonicate.

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