ATN 161

Cat. No. 6058 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： α5β1 integrin receptor antagonist

纯度： ≥95% (HPLC)

引用文献 (4)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ATN 161

ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

技术数据 for ATN 161

分子量	597.65
公式	C₂₃H₃₅N₉O₈S
序列	PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	262438-43-7
PubChem ID	9960285
InChI Key	MMHDBUJXLOFTLC-WOYTXXSLSA-N
Smiles	CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ATN 161

溶解性	Soluble to 2 mg/ml in water

产品说明书 for ATN 161

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ATN 161

参考文献是支持产品生物活性的出版物。

Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582

Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 16985061

Stoeltzing et al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496 PMID: 12584749

If you know of a relevant reference for ATN 161, please let us know.

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关键词: ATN 161, ATN 161 supplier, ATN161, α5β1, integrin, receptors, alpha5beta1, a5b1, antagonists, antagonism, Integrins, 6058, Tocris Bioscience

4 篇 ATN 161 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ATN 161 的部分引用包括：

Viola et al (2020) Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. Elife 9 PMID: 33026975

Aejaz et al (2019) Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth. iScience 14 199-209 PMID: 30981115

Albarrán-Juárez et al (2018) Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med 215 2655 PMID: 30194266

Giovanni et al (2023) The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer. Cell Death Dis 14 73 PMID: 36717550

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.