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ArMan

Cat. No. 8869 Submit a Review Datasheet / COA / SDS
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Description: DC-SIGN ligand used to target dendritic cells
Chemical Name: N-(4-(((2R,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenethyl)pent-4-ynamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ArMan

ArMan is an aryl mannoside targeting ligand that can be functionalised to the surface of virus like particles (VLPs) via click chemistry. Functionalised particles can be used to target DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) dendritic cells to promote selective coengagement of DC-SIGN and TLR7, resulting in a Th1-type immune response. In vivo, immunization with VLP-ArMan-OvaI/II significantly inhibits tumor growth in a murine melanoma model.

Technical Data for ArMan

M. Wt 379.41
Formula C19H25NO7
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 170958390
InChI Key DJVWDLGJYGPTMN-IQRFUGTFSA-N
Smiles OC[C@@H](O[C@H](OC1=CC=C(C=C1)CCNC(CCC#C)=O)[C@H]2O)[C@@H](O)[C@@H]2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ArMan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.94 100

Preparing Stock Solutions for ArMan

The following data is based on the product molecular weight 379.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for ArMan

References are publications that support the biological activity of the product.

Lensch et al (2024) Carbohydrate-lectin interactions reprogram dendritic cells to promote type 1 anti-tumor immunity. ACS Nano 18 26770 PMID: 39283240

Alam et al (2021) Glycan-modified virus-like particles evoke T helper type 1-like immune responses. ACS Nano 15 309 PMID: 32790346

If you know of a relevant reference for ArMan, please let us know.

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Keywords: ArMan, ArMan supplier, ligands, dendritic, cells, specific, intercellular, adhesion, molecule-3, grabbing, nonintegrin, in, vivo, click, chemistry, virus-like, particles, arylmannoside, VLP, Toll-like, receptor, TLR, Biochemicals, and, Molecular, Biology, Receptors, 8869, Tocris Bioscience

Citations for ArMan

Citations are publications that use Tocris products.

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