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Submit ReviewAtosiban
说明： Potent oxytocin receptor antagonist
纯度： ≥98% (HPLC)
生物活性 for Atosiban
Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.
技术数据 for Atosiban
| 分子量 | 994.19 |
| 公式 | C43H67N11O12S2 |
| 序列 |
XYITNCPXG (Modifications: X-1 = Mpr, Tyr-2 = D-Tyr(OEt), X-8 = Orn, Gly-9 = C-terminal amide, Cyclized: X-1 - Cys-6) |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 90779-69-4 |
| PubChem ID | 5311010 |
| InChI Key | VWXRQYYUEIYXCZ-OBIMUBPZSA-N |
| Smiles | [H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Atosiban
| 溶解性 | Soluble to 50 mg/ml in water |
产品说明书 for Atosiban
参考文献 for Atosiban
参考文献是支持产品生物活性的出版物。
Kim et al (2016) The oxyt. receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signalling. Mol.Cell.Endocrinol. 420 11 PMID: 26586210
Kim et al (2017) Differential effects of oxyt. receptor antagonists, Atosiban and Nolasiban, on oxyt. receptor-mediated signaling in human amnion and myometrium. Mol.Pharmacol. 91 403 PMID: 28188254
Hahn et al (1987) Evaluation of 1-deamino-[D-Tyr(Oethyl)2, Thr4, Orn8] vasotocin, an oxyt. antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent. Am.J.Obstet.Gynecol. 157 977 PMID: 3674173
Maggi et al (1994) Antagonists for the human oxyt. receptor: an in vitro study. J.Reprod.Fertil. 101 345 PMID: 7932368
If you know of a relevant reference for Atosiban, please let us know.
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关键词: Atosiban, Atosiban supplier, oxytoxin, receptor, antagonists, antagonism, tocolytics, preterm, labor, labour, OTR, Oxytocin, Receptors, 6332, Tocris Bioscience
4 篇 Atosiban 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Atosiban 的部分引用包括：
Yoshiyuki et al (2020) Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats. Int J Mol Sci 21 PMID: 33271955
Li et al (2021) Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation Cell Rep 36 109411 PMID: 34289348
Xiaobing et al (2021) Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology 46 1045-1056 PMID: 33495546
Silke et al (2022) Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping. Front Cell Neurosci 16 1000538 PMID: 36263085
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Atosiban 的评论
平均评分: 5 (Based on 1 Review.)
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Inhibition of oxytocin receptor.
By
Mohammad Alqudah on 10/19/2022
分析类型： In Vitro
种属： Rat
细胞系/组织： Smooth muscle
10 uM of atosiban 10 to 15 min in an organ bath to block oxytocin-induced contraction of gut smooth muscle strips
