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ATP disodium salt

Cat. No. 3245 3 篇引用文献 5 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： P2 agonist
化学名： Adenosine 5'-triphosphate disodium salt
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (5)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ATP disodium salt

ATP disodium salt is a P2 purinoceptor agonist.

技术数据 for ATP disodium salt

分子量 551.14
公式 C10H14N5Na2O13P3
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 987-65-5
PubChem ID 13803
InChI Key TTWYZDPBDWHJOR-IDIVVRGQSA-L
Smiles O[C@@H]1[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ATP disodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 55.11 100

制备储备液 for ATP disodium salt

以下数据基于产品分子量 551.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.14 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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产品说明书 for ATP disodium salt

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ATP disodium salt

参考文献是支持产品生物活性的出版物。

Gordon (1986) Extracellular ATP: effects, sources and fate. Biochem.J 233 309 PMID: 3006665

Guilbert et al (1998) Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein. Br.J.Pharm. 123 1732

Burnstock and Kenned (2006) Historical review: ATP as a neurotransmitter. Trends Pharm.Sci. 27 16

If you know of a relevant reference for ATP disodium salt, please let us know.

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关键词: ATP disodium salt, ATP disodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, Adenosine, 5'-triphosphate, disodium, salt, 3245, Tocris Bioscience

3 篇 ATP disodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ATP disodium salt 的部分引用包括：

Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Purinergic Signal 288 27434 PMID: 23940034

Taheri et al (2017) Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling. Front Syst Neurosci 11 79 PMID: 29109680

Song et al (2015) Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Neuropharmacology 11 203 PMID: 25682129

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ATP disodium salt 的评论

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great to use for the synthesis of complexes and for its use in biological assays.
By Anonymous on 07/02/2019
种属： Human

I used it to prepare a complex at 1mM concentration.

The product is highly soluble in water thus the most suitable solvent for it to use.

Kinase Assay ATP Kinetics.
By Brian Englar on 02/06/2019
分析类型： In Vitro
种属： Human

Used this ATP for kinase assays with IRAK4 and a TAK1 inhibitor to determine Km and Vmax. Worked well with no issues and can freeze thaw with no issues.

review image
Great for kinase assays and kinetics.
By Scott Scarneo on 02/06/2019
分析类型： In Vitro
种属： Human

I used this product for a kinase assay to look at enzyme kinetics. Worked great and was pure with no issues on solubility or contamination.

review image
Exreacellular ATP stimulates IL-1b production in macrophages.
By Chintan Koyani on 10/23/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Macrophages

RAW macrophages were incubated with ATP (5 mM) for 4 h to follow IL-1b mRNA expression using qPCR. ATP treatment induced inflammatory signalling in macrophages most likely via P2 receptor.

review image
P2 agonist.
By Anonymous on 05/17/2018
分析类型： Ex Vivo
种属： Mouse

ATP, as expected, activates multiple P2 receptor responses, in cell culture and in brain slices.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.