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Submit ReviewAY-NH2
说明： Selective PAR4 agonist
别名： AYPGKF-NH2
纯度： ≥95% (HPLC)
生物活性 for AY-NH2
AY-NH2 is a selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.
技术数据 for AY-NH2
| 分子量 | 680.8 |
| 公式 | C34H48N8O7 |
| 序列 |
AYPGKF (Modifications: Phe-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 352017-71-1 |
| PubChem ID | 9987061 |
| InChI Key | BBAOHIALRKLBRD-OZDPOCAXSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AY-NH2
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for AY-NH2
参考文献 for AY-NH2
参考文献是支持产品生物活性的出版物。
Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728 PMID: 10779527
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
If you know of a relevant reference for AY-NH2, please let us know.
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关键词: AY-NH2, AY-NH2 supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, AYPGKF-NH2, Protease-Activated, Receptors, 1487, Tocris Bioscience
4 篇 AY-NH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AY-NH2 的部分引用包括：
de la Fuente et al (2020) Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange. Biochemistry 59 671 PMID: 31957446
Peng et al (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function. Front Immunol 10 1311 PMID: 31275306
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Oncogene 21 4852 PMID: 25944998
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