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AZ 14145845

Cat. No. 8023 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual Mer/Axl inhibitor
化学名： 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZ 14145845

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively). In vivo, AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with tumors derived from MC38 cells in vivo. AZ 14145845 is orally bioavailable.

技术数据 for AZ 14145845

分子量 561.69
公式 C32H35N9O
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 2830555-70-7
PubChem ID 156596359
InChI Key CZIXXCVLEHVEBZ-UHFFFAOYSA-N
Smiles CC1=C(N=CC(C2=C(C)N(C)N=C2C)=C1)C3=NN=C(N(CC4=CN5C(C6=CC=C(CN(C)C)C=C6)=CN=C5C=C4)C)O3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 14145845

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.17 100
ethanol 56.17 100

制备储备液 for AZ 14145845

以下数据基于产品分子量 561.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.9 mL 17.8 mL
5 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for AZ 14145845

参考文献是支持产品生物活性的出版物。

McCoull et al (2021) Optimization of an Imidazo[1,2.a]pyridine series to afford highly selective type I1/2 Dual Mer/Axl kinase inhibitors with in vivo efficacy. J.Med.Chem. 64 13524 PMID: 34478292

If you know of a relevant reference for AZ 14145845, please let us know.

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关键词: AZ 14145845, AZ 14145845 supplier, AZ14145845, potent, selective, Mer, Axl, kinases, inhibitors, inhibits, receptor, tyrosine, in, vivo, orally, bioavailable, cancer, immunology, Other, RTKs, 8023, Tocris Bioscience

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