主页 / 药理学 / GPCRs / 7-TM Receptors / Free Fatty Acid Receptors / Free Fatty Acid Receptor Agonists / AZ 1729

AZ 1729

Cat. No. 6826 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： FFA2 allosteric agonist; displays bias for the Gi signaling pathway
化学名： 4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZ 1729

AZ 1729 is a FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.

技术数据 for AZ 1729

分子量 369.42
公式 C18H16FN5OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2016864-46-1
InChI Key HULFYSCAJVTAAR-UHFFFAOYSA-N
Smiles CC1=C(C2=CC(NC(C3=CC=C(C=C3)F)=O)=CC=C2)SC(NC(N)=N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 1729

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.94 100
ethanol 1.85 5

制备储备液 for AZ 1729

以下数据基于产品分子量 369.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for AZ 1729

参考文献是支持产品生物活性的出版物。

Bolognini et al (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. J.Biol.Chem. 291 18915 PMID: 27385588

Sergeev et al (2017) A single extracellular amino acid in free fatty acid receptor 2 defines antagonist species selectivity and G protein selection bias. Sci.Rep. 7 13741 PMID: 29061999

If you know of a relevant reference for AZ 1729, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Free Fatty Acid Receptor Agonists

关键词: AZ 1729, AZ 1729 supplier, AZ1729, free, fatty, acid, receptor, 2, biased, allosteric, agonists, agonism, functional, PAM, NAM, modulators, modulates, FFA2, GPCR, signaling, Free, Fatty, Acid, Receptors, 6826, Tocris Bioscience

篇 AZ 1729 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 AZ 1729 的引用文献。 您是否知道使用了 Tocris AZ 1729 的优秀论文？ 请告知我们.

AZ 1729 的评论

目前没有该产品的评论。 Be the first to review AZ 1729 and earn rewards!

Have you used AZ 1729?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review