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Submit ReviewAZD 2066
说明： mGlu5 antagonist; orally bioavailable and brain penetrant
化学名： 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine
纯度： ≥98% (HPLC)
生物活性 for AZD 2066
AZD 2066 is an mGlu5 antagonist. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.
化合物库 for AZD 2066
AZD 2066 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AZD 2066
| 分子量 | 381.82 |
| 公式 | C19H16ClN5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 934282-55-0 |
| PubChem ID | 16041426 |
| InChI Key | SXWHYTICXCLKDG-GFCCVEGCSA-N |
| Smiles | CN1C(C2=CC=NC=C2)=NN=C1O[C@H](C)C3=NOC(C4=CC=CC(Cl)=C4)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AZD 2066
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 38.18 | 100 | |
| ethanol | 38.18 | 100 |
制备储备液 for AZD 2066
以下数据基于产品分子量 381.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.1 mL | 26.19 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for AZD 2066
参考文献 for AZD 2066
参考文献是支持产品生物活性的出版物。
Swedberg et al (2014) AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 350 212 PMID: 24876235
If you know of a relevant reference for AZD 2066, please let us know.
关键词: AZD 2066, AZD 2066 supplier, AZD2066, mGlu5, antagonists, metabotropic, glutamate, receptors, orally, bioavailable, brain, penetrant, Glutamate, (Metabotropic), Group, I, Receptors, 5614, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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