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Submit ReviewAzilsartan
Discontinued Product
4553 has been discontinued.
View all Angiotensin AT<sub>1</sub> Receptors products.
说明： Potent AT1 inverse agonist; antihypertensive
化学名： 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Azilsartan
Azilsartan is a potent angiotensin II type 1 (AT1) receptor inverse agonist (IC50 = 2.6 nM at the human AT1 receptor). Inhibits angiotensin II-induced IP1 accumulation in COS-7 cells; decreases maximal contraction of rabbit aortic strips in a concentration-dependent manner (pD'2 = 9.9). Antihypertensive; prevents vascular cell proliferation and expression of PAI-1.
化合物库 for Azilsartan
Azilsartan is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Azilsartan
| 分子量 | 456.45 |
| 公式 | C25H20N4O5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 147403-03-0 |
| PubChem ID | 9825285 |
| InChI Key | KGSXMPPBFPAXLY-UHFFFAOYSA-N |
| Smiles | O=C1NC(C2=CC=CC=C2C(C=C5)=CC=C5CN4C3=C(C(O)=O)C=CC=C3N=C4OCC)=NO1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Azilsartan
参考文献 for Azilsartan
参考文献是支持产品生物活性的出版物。
Kajiya et al (2011) Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J.Hypertens. 29 2476 PMID: 21986624
French et al (2011) The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaques. J.Cardiovasc.Pharmacol. 58 143 PMID: 21558880
Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673
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