Azimilide dihydrochloride

Name: Azimilide dihydrochloride
Brand: Tocris Bioscience
SKU: 6318
Rating: 5 (1 reviews)

Cat. No. 6318 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： K_v11.1 (hERG) channel blocker

化学名： 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Azimilide dihydrochloride

Azimilide dihydrochloride is a K_v11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K⁺ currents (IC₅₀ of 0.4 mM and 3 mM, respectively). Also inhibits Na⁺/Ca²⁺ exchanger in vitro. Shows inhibition of Na⁺ currents, L-type Ca²⁺ currents and other K⁺ currents at high concentrations.

技术数据 for Azimilide dihydrochloride

分子量	530.88
公式	C₂₃H₂₈ClN₅O₃.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	149888-94-8
PubChem ID	6435819
InChI Key	HHPSICLSNHCSNZ-DSHYBBOZSA-N
Smiles	CN1CCN(CC1)CCCCN2C(CN(C2=O)/N=C/C3=CC=C(C4=CC=C(C=C4)Cl)O3)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Azimilide dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	26.54	50

制备储备液 for Azimilide dihydrochloride

以下数据基于产品分子量 530.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.77 mL	18.84 mL	37.67 mL
2.5 mM	0.75 mL	3.77 mL	7.53 mL
5 mM	0.38 mL	1.88 mL	3.77 mL
25 mM	0.08 mL	0.38 mL	0.75 mL

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产品说明书 for Azimilide dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Azimilide dihydrochloride

参考文献是支持产品生物活性的出版物。

Watanabe and Kimura (2010) Inhibitory Effect of Azimilide on Na⁺/Ca²⁺ Exchange Current in Guinae-Pig Cardiac Myocytes. J.Pharmacol.Sci. 114 111 PMID: 20710119

Busch et al (1998) Blockade of HERG channels by the class III antiarrhythmic Azimilide: mode of action. Br.J.Pharmacol. 123 23 PMID: 9484850

Busch et al (1995) Blockade of Human IsK channels expression in Xenopus oocytes by the novel class III antiarrhythmic NE-10064. Eur.J.Pharmacol. 264 33 PMID: 7828640

Fermini et al (1995) Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarisation: block of delayed rectifier potassium and L-type calcium currents. J.Cardiovasc.Pharmacol. 26 259 PMID: 7475051

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关键词: Azimilide dihydrochloride, Azimilide dihydrochloride supplier, potassium, channel, blockers, Kv11.1, hERG, blocks, Voltage-Gated, Potassium, Channels, Na+/Ca2+, Exchanger, 6318, Tocris Bioscience

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