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Submit Reviewβ-Funaltrexamine hydrochloride
Discontinued Product
0926 has been discontinued.
说明： Irreversible and selective μ antagonist
别名： β-FNA
化学名： (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
纯度： ≥98% (HPLC)
生物活性 for β-Funaltrexamine hydrochloride
β-Funaltrexamine hydrochloride is a selective μ opioid receptor antagonist.
许可信息
Sold with the permission of the University of Minnesota
技术数据 for β-Funaltrexamine hydrochloride
| 分子量 | 490.99 |
| 公式 | C25H30N2O6.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 72786-10-8 |
| PubChem ID | 44522395 |
| InChI Key | BIPHUOBUKMPSQR-NQGXHZAGSA-N |
| Smiles | Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)\C=C\C(=O)OC)=CC=C3O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for β-Funaltrexamine hydrochloride
参考文献 for β-Funaltrexamine hydrochloride
参考文献是支持产品生物活性的出版物。
Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986
Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltr. Eur.J.Pharmacol. 70 445 PMID: 6263637
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关键词: beta-Funaltrexamine hydrochloride, beta-Funaltrexamine hydrochloride supplier, Irreversible, μ-opioid, mu-opioid, selective, antagonists, MOP, Receptors, OP3, β-Funaltrexamine, beta-Funaltrexamine, hydrochloride, β-FNA, beta-FNA, b-FNA, Mu, Opioid, 0926, Tocris Bioscience
7 篇 β-Funaltrexamine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 β-Funaltrexamine hydrochloride 的部分引用包括：
Crowley et al (2020) Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor. ACS Chem Neurosci 11 1781 PMID: 32383854
Phillips et al (2012) Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression. J Neurophysiol 108 2393 PMID: 22956800
Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986 PMID: 20977451
Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Neuropsychopharmacology 10 e0145556 PMID: 26700862
Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Ins Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752 PMID: 21785619
Cecchi et al (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res 194 146 PMID: 18656501
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation 38 1296 PMID: 23348063
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