μ Opioid Receptors
The μ opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and NOP receptors. Three splice variants of the receptor (designated μ1, μ2 and μ3) have been characterized.
μ Opioid Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1171 | DAMGO |
| Selective μ agonist | |
| 0840 | Loperamide hydrochloride |
| Peripherally acting μ agonist; Ca2+ channel blocker | |
| 7218 | PZM21 |
| Selective μ receptor agonist | |
μ Opioid Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 0898 | Clocinnamox mesylate |
| Irreversible μ antagonist | |
| 1560 | CTAP |
| Potent and selective μ antagonist | |
| 1578 | CTOP |
| Potent and selective μ antagonist | |
| 2601 | Cyprodime hydrochloride |
| Selective μ antagonist | |
The μ opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and NOP receptors. Three variants of the receptor (designated μ1, μ2 and μ3) have been characterized, arising from the alternative splicing of the this gene.
μ Opioid receptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus, amygdala) and in the peripheral nervous system (myenteric neurons and vas deferens). μ opioid receptors have been implicated in respiration, cardiovascular functions, feeding, learning and memory, intestinal transit, locomotor activity, thermoregulation, hormone secretion and immune functions. The human gene encoding the μ opioid receptor has been localized to chromosome 6 (6q24-q25).
External sources of pharmacological information for μ Opioid Receptors :
Literature for μ Opioid Receptors
Tocris offers the following scientific literature for μ Opioid Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
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