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B I09

Cat. No. 6009 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： IRE1 endonuclease inhibitor; cell permeable
化学名： 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for B I09

B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

化合物库 for B I09

B I09 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for B I09

分子量 303.31
公式 C16H17NO5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1607803-67-7
PubChem ID 86290458
InChI Key UYYMWNUDIOPESF-UHFFFAOYSA-N
Smiles OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for B I09

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 15.17 50

制备储备液 for B I09

以下数据基于产品分子量 303.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.59 mL 32.97 mL 65.94 mL
2.5 mM 1.32 mL 6.59 mL 13.19 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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产品说明书 for B I09

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for B I09

参考文献是支持产品生物活性的出版物。

Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669

If you know of a relevant reference for B I09, please let us know.

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关键词: B I09, B I09 supplier, BI09, IRE, inhibitors, inhibits, cell, permeable, in, vivo, active, RNAse, endonuclease, IRE1, 6009, Tocris Bioscience

1 篇 B I09 的引用文献

引用文献是使用了 Tocris 产品的出版物。 B I09 的部分引用包括：

Andrew V et al (2021) Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. Cancer Res 81 5325-5335 PMID: 34548333

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该领域的文献

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