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Submit Reviewβ-Lapachone
说明： DNA topoisomerase I inhibitor
化学名： 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
纯度： ≥98% (HPLC)
生物活性 for β-Lapachone
β-Lapachone is a DNA topoisomerase I inhibitor. Exhibits a different inhibitory mechanism to camptothecin (Cat. No. 1100). Induces apoptosis in a variety of cell lines, including prostate cancer and promyelocytic leukemia cells; blocks the cell cycle in G0/G1. Also has effects on DNA topoisomerase II, NF-κB, AP-1, and JNK.
化合物库 for β-Lapachone
beta-Lapachone is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for β-Lapachone
| 分子量 | 242.27 |
| 公式 | C15H14O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 4707-32-8 |
| PubChem ID | 3885 |
| InChI Key | QZPQTZZNNJUOLS-UHFFFAOYSA-N |
| Smiles | O=C(C(C3=C2OC(C)(C)CC3)=O)C1=C2C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for β-Lapachone
参考文献 for β-Lapachone
参考文献是支持产品生物活性的出版物。
Li et al (1993) Beta-Lapachone, a novel topoisomerase I inhibitor with a mode of action different from camptothecin. J.Biol.Chem. 268 22463 PMID: 8226754
Manna et al (1999) Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β lapachone. Biochem.Pharmacol. 57 763 PMID: 10075082
Shiah et al (1999) Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway Cancer Res. 59 391 PMID: 9927052
Wuerzberger et al (1998) Induction of apoptosis in MCF-7:WS8 breast cancer cells by β-Lapachone. Cancer Res. 58 1876 PMID: 9581828
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关键词: beta-Lapachone, beta-Lapachone supplier, DNA, topoisomerase, I, inhibitors, inhibits, apoptosis, proapoptotic, b-lapachone, beta-lapachone, β-lapachone, Topoisomerase, 1293, Tocris Bioscience
1 篇 β-Lapachone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 β-Lapachone 的部分引用包括：
Joshi et al (2016) Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1. Cell Death Differ 23 216 PMID: 26138443
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.