BADGE

Name: BADGE
Brand: Tocris Bioscience
SKU: 1326

Cat. No. 1326 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1326 has been discontinued.

View all PPARγ products.

说明： PPARγ antagonist

别名： Bisphenol A diglycidyl ether

化学名： 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane

纯度： ≥95%

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for BADGE

PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.

技术数据 for BADGE

分子量	340.42
公式	C₂₁H₂₄O₄
储存	Desiccate at -20°C
纯度	≥95%
CAS Number	1675-54-3
PubChem ID	2286
InChI Key	LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Smiles	CC(C)(C1=CC=C(OCC2CO2)C=C1)C1=CC=C(OCC2CO2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BADGE

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BADGE

参考文献是支持产品生物活性的出版物。

Bishop-Bailey et al (2000) Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line. Br.J.Pharmacol. 131 651 PMID: 11030710

Cuzzocrea et al (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. Eur.J.Pharmacol. 483 79 PMID: 14709329

Fehlberg et al (2003) Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO. Br.J.Pharmacol. 139 495 PMID: 12788809

Wright et al (2000) A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J.Biol.Chem. 275 1873 PMID: 10636887

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关键词: BADGE, BADGE supplier, PPARγ, PPARgamma, antagonists, Peroxisome, Proliferator-activating, Receptors, PPARs, BisphenolA, diglycidyl, ether, Bisphenol, A, 1326, Tocris Bioscience