PPARγ
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.
PPARγ Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 4784 | Edaglitazone |
| Potent and selective PPARγ agonist; antidiabetic | |
| 1664 | GW 1929 hydrochloride |
| Selective PPARγ agonist. Orally active | |
| 4124 | Pioglitazone hydrochloride |
| Selective PPARγ agonist; antidiabetic agent | |
| 5325 | Rosiglitazone |
| Potent and selective PPARγ agonist; antidiabetic agent | |
| 3114 | Troglitazone |
| Selective PPARγ agonist; antidiabetic agent | |
Partial Agonists |
|
| Cat. No. | Product Name / Activity |
| 7423 | INT 131 |
| PPARγ partial agonist | |
| 2150 | nTZDpa |
| Potent, selective PPARγ partial agonist | |
PPARγ Antagonists |
|
| Cat. No. | Product Name / Activity |
| 1508 | GW 9662 |
| Selective covalent PPARγ antagonist | |
| 6383 | SR 16832 |
| Dual site PPARγ inhibitor | |
| 2022 | SR 202 |
| Selective PPARγ antagonist; antidiabetic and antiobesity agent | |
| 2301 | T 0070907 |
| Highly potent and selective covalent PPARγ antagonist | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1110 | Genistein |
| PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor | |
| 5920 | LG 100268 |
| Activates RXR/PPARγ heterodimers; potent and selective RXR agonist | |
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 (3p25).