BAY 41-8543

Pricing Availability   Qty
说明: Guanylyl cyclase (sGC) stimulator
化学名: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
纯度: ≥98% (HPLC)
说明书
引用文献
评论

生物活性 for BAY 41-8543

BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

技术数据 for BAY 41-8543

分子量 420.44
公式 C21H21FN8O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 256498-66-5
PubChem ID 9953906
InChI Key AQYFUZRYBJBAGZ-UHFFFAOYSA-N
Smiles FC1=CC=CC=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=CC=CN=C52

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 41-8543

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.2 10 温和加热

制备储备液 for BAY 41-8543

以下数据基于产品分子量 420.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 23.78 mL 118.92 mL 237.85 mL
0.5 mM 4.76 mL 23.78 mL 47.57 mL
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

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参考文献 for BAY 41-8543

参考文献是支持产品生物活性的出版物。

Stasch et al (2002) Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 135 333 PMID: 11815368

Hoffmann et al (2015) Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 6 7235 PMID: 26011238


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