BAY 58-2667 hydrochloride

Cat. No. 6052 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent soluble guanylyl cyclase (sGC) activator

别名： Cinaciguat hydrochloride

化学名： 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BAY 58-2667 hydrochloride

BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC₅₀ = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

技术数据 for BAY 58-2667 hydrochloride

分子量	602.16
公式	C₃₆H₃₉NO₅.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	646995-35-9
PubChem ID	10031513
InChI Key	LLHMBJOVHATVSP-UHFFFAOYSA-N
Smiles	OC(CCCCN(CC1=CC=C(C(O)=O)C=C1)CCC2=C(C=CC=C2)OCC3=CC=C(C=C3)CCC4=CC=CC=C4)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 58-2667 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	60.22	100

制备储备液 for BAY 58-2667 hydrochloride

以下数据基于产品分子量 602.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.3 mL	16.61 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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产品说明书 for BAY 58-2667 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BAY 58-2667 hydrochloride

参考文献是支持产品生物活性的出版物。

Stasch et al (2002) NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 136 773 PMID: 12086987

Stasch et al (2006) Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 116 2552 PMID: 16955146

Roy et al (2008) Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 153 1495 PMID: 18204474

If you know of a relevant reference for BAY 58-2667 hydrochloride, please let us know.

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2 篇 BAY 58-2667 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAY 58-2667 hydrochloride 的部分引用包括：

Cheng et al (2019) Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol ATVBAHA119312725 PMID: 31043077

John et al (2022) Modulation of soluble guanylate cyclase ameliorates pulmonary hypertension in a rat model of chronic thromboembolic pulmonary hypertension by stimulating angiogenesis. Physiol Rep 10 e15156 PMID: 35001565

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