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Submit ReviewBay 59-3074
说明： CB1/CB2 receptor partial agonist
化学名： 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester
纯度： ≥99% (HPLC)
生物活性 for Bay 59-3074
Bay 59-3074 is a novel CB1/CB2 receptor partial agonist (Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Orally active CB1 agonist in vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.
许可信息
Sold for research purposes under agreement from Bayer
技术数据 for Bay 59-3074
| 分子量 | 453.35 |
| 公式 | C18H13F6NO4S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 406205-74-1 |
| PubChem ID | 10479060 |
| InChI Key | LWUSZIVDPJPVBW-UHFFFAOYSA-N |
| Smiles | FC(F)(F)CCCS(=O)(=O)OC1=CC(OC2=CC=CC(=C2C#N)C(F)(F)F)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Bay 59-3074
参考文献 for Bay 59-3074
参考文献是支持产品生物活性的出版物。
De Vry et al (2004) 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effects. J.Pharmacol.Exp.Ther. 310 620 PMID: 15140913
De Vry et al (2004) Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 505 127 PMID: 15556145
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关键词: Bay 59-3074, Bay 59-3074 supplier, CB1/CB2, receptor, partial, agonists, cannabinoids, Non-Selective, Receptors, Bay59-3074, cb2r, cb1r, Non-selective, Cannabinoids, 2500, Tocris Bioscience
2 篇 Bay 59-3074 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Bay 59-3074 的部分引用包括：
McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Biol Psychiatry 14 49 PMID: 19171920
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.