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Submit ReviewBAY 8002
说明： Potent dual MCT1/2 inhibitor; orally bioavailable
化学名： 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for BAY 8002
BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.
技术数据 for BAY 8002
| 分子量 | 415.85 |
| 公式 | C20H14ClNO5S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 724440-27-1 |
| PubChem ID | 992293 |
| InChI Key | CLAUJSRBKSRTGQ-UHFFFAOYSA-N |
| Smiles | OC(C1=C(C=CC=C1)NC(C2=C(C=CC(S(=O)(C3=CC=CC=C3)=O)=C2)Cl)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BAY 8002
参考文献 for BAY 8002
参考文献是支持产品生物活性的出版物。
Quanz et al (2018) Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol.Cancer Ther. 17 2285 PMID: 30115664
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关键词: BAY 8002, BAY 8002 supplier, BAY8002, potent, dual, MCT1/2, inhibitors, inhibits, MCT1, MCT2, orally, bioavailable, lactate, Monocarboxylate, Transporters, 6817, Tocris Bioscience
1 篇 BAY 8002 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BAY 8002 的部分引用包括：
Keit Men et al (2020) A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci 23 1215-1228 PMID: 32807950
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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