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BAY 876

Cat. No. 6199 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective GLUT1 inhibitor
化学名： N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 876

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

External Portal Information for BAY 876

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.

技术数据 for BAY 876

分子量 496.42
公式 C24H16F4N6O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1799753-84-6
PubChem ID 118191391
InChI Key BKLJDIJJOOQUFG-UHFFFAOYSA-N
Smiles O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 876

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.64 100

制备储备液 for BAY 876

以下数据基于产品分子量 496.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for BAY 876

参考文献是支持产品生物活性的出版物。

Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707

Ma et al (2018) Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers (Basel) 11 33 PMID: 30602670

If you know of a relevant reference for BAY 876, please let us know.

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关键词: BAY 876, BAY 876 supplier, BAY876, potent, selective, GLUT1, inhibitors, inhibits, cell, permeable, orally, bioavailable, Glucose, Transporters, 6199, Tocris Bioscience

2 篇 BAY 876 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAY 876 的部分引用包括：

Jessica E et al (2022) Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu. Fluids Barriers CNS 19 10 PMID: 35123529

Ole et al (2022) YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. Dev Cell 57 212-227.e8 PMID: 34990589

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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