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BAY-u 3405

Cat. No. 2732 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual TP/DP2 (CRTH2) receptor antagonist
别名： Ramatroban
化学名： (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY-u 3405

BAY-u 3405 is a potent dual antagonist of TP/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively). Suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM).

技术数据 for BAY-u 3405

分子量 416.47
公式 C21H21FN2O4S
储存 Desiccate at -20°C
纯度 ≥99% (HPLC)
CAS Number 116649-85-5
PubChem ID 123879
InChI Key LDXDSHIEDAPSSA-OAHLLOKOSA-N
Smiles FC(C=C4)=CC=C4S(N[C@@H](C3)CCC2=C3C1=CC=CC=C1N2CCC(O)=O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY-u 3405

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.65 100
ethanol 41.65 100

制备储备液 for BAY-u 3405

以下数据基于产品分子量 416.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for BAY-u 3405

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for BAY-u 3405

参考文献是支持产品生物活性的出版物。

Sundstrom et al (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J.Pharmacol.Exp.Ther. 307 408 PMID: 12954791

Ishizuka et al (2004) Ramatroban (BAY u3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc.Drug Rev. 22 71 PMID: 15179446

Ulven and Kostenis (2005) Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J.Med.Chem. 48 897 PMID: 15715457

If you know of a relevant reference for BAY-u 3405, please let us know.

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关键词: BAY-u 3405, BAY-u 3405 supplier, Dual, TP/DP2, CRTH2, receptors, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, BAY-u3405, Ramatroban, Receptors, 2732, Tocris Bioscience

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BAY-u 3405 inhibits 15d-PGJ2-induced p38 activation.
By Chintan Koyani on 12/10/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Cardiomyocytes

HL-1 cardiomyocytes were pre-incubated with BAY-u 3405 (2 µM, 30 min) followed by treatment with 15d-PGJ2 (15 µM, 30 min) to follow p38 activation using Western blot analysis. BAY-u 3405 completely abolished 15d-PGJ2-induced p38 phosphorylation.

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