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Submit Review生物活性 for BDNF (human)
BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. BDNF enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. In an animal model of Huntington's disease, BDNF administration or overexpression rescues the disease phenotype.
技术数据 for BDNF (human)
| 分子量 | 26984 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 218441-99-7 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BDNF (human)
| 溶解性 | Soluble in water |
产品说明书 for BDNF (human)
参考文献 for BDNF (human)
参考文献是支持产品生物活性的出版物。
Lipsky and Marini (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 1122 130 PMID: 18077569
Evans and Barker (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 12 437 PMID: 18348680
Wang et al (2008) The when and where of BDNF and the antidepressant response. Biol.Psychiat. 63 640 PMID: 18329441
Zuccato et al (2005) Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol.Res. 52 133 PMID: 15967378
If you know of a relevant reference for BDNF (human), please let us know.
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关键词: BDNF (human), BDNF (human) supplier, activators, TrkB, p75, receptors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, huntingtons, Trk, Organoids, 2837, Tocris Bioscience
6 篇 BDNF (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BDNF (human) 的部分引用包括：
Li et al (2011) Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS One 6 e26065 PMID: 22022509
Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805
Chiara et al (2010) Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. J Neurosci 30 8127 PMID: 20554863
Hossaini et al (2010) Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. Cell Metab 6 43 PMID: 20653942
Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons. Mol Pain 35 4469 PMID: 25762688
Parsons et al (2014) Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem 289 3518 PMID: 24347167
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BDNF (human) 的评论
平均评分: 4.5 (基于 2 条评论。)
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Smooth muscle activation.
By
Mohammad Alqudah on 10/19/2022
分析类型： In Vitro
种属： Rat
细胞系/组织： Smooth muscle
Used to activate primary smooth muscle culture at 1 nM.Good results
Increases neurite outgrowth in human neurons.
By
Karthik Krishnamurthy on 11/15/2021
分析类型： In Vitro
种属： Human
细胞系/组织： iPS neurons
Used at a concentration of 10 ng/ml. Increases neurite growth in human iPS neurons. The image shows the labeling of MAP-2 in human iPS neurons treated with BDNF for a week.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.