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BDS I

Cat. No. 5184 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5184 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
说明： Potent and reversible Kv3.4 potassium channel blocker; neuroprotective
别名： Blood depressing substance 1
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for BDS I

BDS I is a potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.

技术数据 for BDS I

分子量 4708.37
公式 C210H297N57O56S6
序列 AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH

(Modifications: Disulfide bridge: 4-39,6-32,22-40)

储存 Store at -20°C
PubChem ID 90489021
InChI Key NHDQBZJQNKDJOQ-UHFFFAOYSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC1=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N3)[C@@H](C)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BDS I

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BDS I

参考文献是支持产品生物活性的出版物。

Diochot et al (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J.Biol.Chem. 273 6744 PMID: 9506974

Liu et al (2012) Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J.Neurophysiol. 107 3155 PMID: 22442564

Pannaccione et al (2007) Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol.Pharmacol. 72 665 PMID: 17495071

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关键词: BDS I, BDS I supplier, BDSI, blood, depressing, substance, 1, potent, reversible, Kv3.4, potassium, channels, blockers, attenuated, inactivation, sodium, currents, Nav1.7, and, Nav1.3, neuroprotective, venoms, BDS1, BDS, BDS-1, Blood, Voltage-Gated, Potassium, Channels, Voltage-gated, Sodium, 5184, Tocris Bioscience

篇 BDS I 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 BDS I 的引用文献。

BDS I 的评论

平均评分: 5 (Based on 1 Review.)

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Great water soluble toxin for Kv blocking.
By Anonymous on 10/22/2018
分析类型： In Vitro
种属： Human

BDS I toxin is stable, water soluble and thus a suitable choice in Kv3.4 channel activity monitoring.The product worked ideally and gave similar data patterns every single time.

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