Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: Tocris Bioscience
SKU: 4117
Rating: 5 (1 reviews)

Cat. No. 4117 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Non-selective Ca²⁺ channel blocker; also NCX inhibitor

化学名： N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Bepridil hydrochloride

Bepridil hydrochloride is a calcium channel blocker. Also inhibits Na⁺/Ca²⁺ exchange (NCX), sodium channels and cardiac sarcolemmal K_ATP channels; opens mitochondrial K_ATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.

化合物库 for Bepridil hydrochloride

Bepridil hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bepridil hydrochloride

分子量	403
公式	C₂₄H₃₄N₂O.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	68099-86-5
PubChem ID	50088
InChI Key	JXBBWYGMTNAYNM-UHFFFAOYSA-N
Smiles	CC(C)COCC(N3CCCC3)CN(C2=CC=CC=C2)CC1=CC=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bepridil hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.3	100

制备储备液 for Bepridil hydrochloride

以下数据基于产品分子量 403。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.81 mL
5 mM	0.5 mL	2.48 mL	4.96 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for Bepridil hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Bepridil hydrochloride

参考文献是支持产品生物活性的出版物。

Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9 PMID: 2420970

Wantanabe and Kimura (2001) Blocking effect of bepridil on Na⁺/ Ca²⁺ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370 PMID: 11388640

Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial K_ATP channels, blocks sarcolemmal K_ATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182 PMID: 16174795

Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D PMID: 1372785

If you know of a relevant reference for Bepridil hydrochloride, please let us know.

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关键词: Bepridil hydrochloride, Bepridil hydrochloride supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Non-selective, Cav, Channels, Na+/Ca2+, Exchanger, 4117, Tocris Bioscience

3 篇 Bepridil hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bepridil hydrochloride 的部分引用包括：

Yan et al (2019) Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol 176 2691-2707 PMID: 31034096

Xiaoli et al (2022) Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells. Int J Mol Sci 23 PMID: 35055084

Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113 PMID: 23785474

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