BETP

Cat. No. 4778 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Positive allosteric modulator of GLP-1 receptors

化学名： 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BETP

BETP is a selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.

化合物库 for BETP

BETP is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BETP

分子量	406.42
公式	C₂₀H₁₇F₃N₂O₂S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1371569-69-5
PubChem ID	49868481
InChI Key	NTDFYGSSDDMNHI-UHFFFAOYSA-N
Smiles	CCS(C1=NC(C2=CC=CC(OCC3=CC=CC=C3)=C2)=CC(C(F)(F)F)=N1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BETP

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.64	100
	ethanol	20.32	50

制备储备液 for BETP

以下数据基于产品分子量 406.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.3 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for BETP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BETP

参考文献是支持产品生物活性的出版物。

Willard et al (2012) Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the Insotropic effect of oxyntomodulin. Mol.Pharmacol. 82 1066 PMID: 22930710

Sloop et al (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates Ins secretion in rodents and from human islets. Diabetes 59 3099 PMID: 20823098

Cheong et al (2012) Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 417 558 PMID: 22177947

If you know of a relevant reference for BETP, please let us know.

按标靶查看相关产品

关键词: BETP, BETP supplier, Allosteric, modulators, GLP-1, GLP1, receptors, glucagon-like, peptide, agonists, PAM, Glucagon-Like, Peptide, 1, Receptors, 4778, Tocris Bioscience

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该领域的文献

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.