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Submit ReviewBF 2649 hydrochloride
说明： Potent and selective H3 inverse agonist
化学名： 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for BF 2649 hydrochloride
BF 2649 hydrochloride is a potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.
化合物库 for BF 2649 hydrochloride
BF 2649 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BF 2649 hydrochloride
| 分子量 | 332.31 |
| 公式 | C17H26ClNO.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 903576-44-3 |
| PubChem ID | 11551689 |
| InChI Key | XLFKECRRMPOAQS-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BF 2649 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 33.23 | 100 | |
| DMSO | 33.23 | 100 |
制备储备液 for BF 2649 hydrochloride
以下数据基于产品分子量 332.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.05 mL | 30.09 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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产品说明书 for BF 2649 hydrochloride
参考文献 for BF 2649 hydrochloride
参考文献是支持产品生物活性的出版物。
Ligneau et al (2007) Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 73 1215 PMID: 17343831
Ligneau et al (2007) BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 320 365 PMID: 17005916
If you know of a relevant reference for BF 2649 hydrochloride, please let us know.
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关键词: BF 2649 hydrochloride, BF 2649 hydrochloride supplier, BF2649, HCl, histamine, receptor, H3, histaminergic, antagonists, inverse, agonists, nootropic, Histamine, Receptors, 3743, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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