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BGP 15

Cat. No. 6703 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PARP inhibitor; cytoprotectant
化学名： N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BGP 15

BGP 15 is a PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. BGP 15 also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

技术数据 for BGP 15

分子量 351.27
公式 C14H22N4O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 66611-37-8
PubChem ID 70701185
InChI Key ISGGVCWFTPTHIX-UHFFFAOYSA-N
Smiles OC(CN1CCCCC1)CONC(C2=CN=CC=C2)=N.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BGP 15

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 35.13 100
DMSO 7.03 20 温和加热

制备储备液 for BGP 15

以下数据基于产品分子量 351.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.47 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for BGP 15

参考文献是支持产品生物活性的出版物。

Szabados et al (2000) BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 59 937 PMID: 10692558

Racz et al (2002) BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 63 1099 PMID: 11931842

Henstridge et al (2014) Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 63 1881 PMID: 24430435

Ohlen et al (2017) BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 114 5035 PMID: 28439028

Chung et al (2008) HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 105 1739 PMID: 18223156

If you know of a relevant reference for BGP 15, please let us know.

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关键词: BGP 15, BGP 15 supplier, BGP15, cytoprotectant, chemoprotectant, PARP, inhibitors, inhibits, Hsp70, protein, 1, Hsp72, activators, activates, Poly(ADP-ribose), Polymerase, 6703, Tocris Bioscience

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