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BI-6901

Cat. No. 6141 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective CCR10 antagonist
化学名： N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BI-6901

BI-6901 is a potent and selective CCR10 antagonist (IC50 = 1 - 25 nM). BI-6901 inhibits CCL27-dependent chemotaxis of Ba/F3 cells (IC50 = 1 nM) and reduces inflammation in a DNFB-stimulated animal model of contact hypersensitivity.

技术数据 for BI-6901

分子量 453.56
公式 C23H27N5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2040401-92-9
PubChem ID 131801164
InChI Key BRJXJOWXAFLRTE-OAQYLSRUSA-N
Smiles CC1CCN(C([C@H](NS(=O)(C2=C3C=CNC3=CC=C2)=O)CCN4C=CC=C4C#N)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BI-6901

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.36 100
ethanol 45.36 100

制备储备液 for BI-6901

以下数据基于产品分子量 453.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for BI-6901

参考文献是支持产品生物活性的出版物。

Abeywardane et al (2016) N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg.Med.Chem.Lett. 26 5277 PMID: 27692854

If you know of a relevant reference for BI-6901, please let us know.

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关键词: BI-6901, BI-6901 supplier, BI6901, eut22, potent, selective, chemokines, receptors, antagonists, chemotaxis, inflammation, antiinflammatory, anti-inflammatory, CCR10, Chemokine, CC, Receptors, 6141, Tocris Bioscience

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