Chemokine CC Receptors

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, although a small subgroup has six cysteines, with the first two cysteines being adjacent to one another. There are 10 chemokine CC receptors, with each one having a distinct chemokine and leukocyte specificity.

CC chemokines have a key role in the recruitment of monocytes and macrophages, cells types that are important in a number of chronic inflammatory conditions, such as atherosclerosis, rheumatoid arthritis, adipose inflammation, multiple sclerosis, asthma and Crohn's disease. CCR antagonists have been investigated clinically for these and other disorders. In addition, CCR5 acts as a coreceptor for HIV entry into CD4⁺ cells and antagonists of CCR5, such as maraviroc, have been developed to treat HIV infection.

External sources of pharmacological information for Chemokine CC Receptors :

• IUPHAR Receptor Code

• BJP Guide

Literature for Chemokine CC Receptors

Tocris offers the following scientific literature for Chemokine CC Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.

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Chemokine CC Receptor Gene Data