BIBU 1361 dihydrochloride

Name: BIBU 1361 dihydrochloride
Brand: Tocris Bioscience
SKU: 2417

Cat. No. 2417 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2417 has been discontinued.

View all EGFR products.

说明： Selective inhibitor of EGFR-kinase

化学名： N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for BIBU 1361 dihydrochloride

BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC₅₀ = 290 nM) and is selective over a range of other related tyrosine kinases (IC₅₀ > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

技术数据 for BIBU 1361 dihydrochloride

分子量	516.87
公式	C₂₂H₂₇ClFN₇.2HCl
储存	Desiccate at +4°C
纯度	≥97% (HPLC)
CAS Number	1643609-75-9
PubChem ID	46861539
InChI Key	ZNNWCQCQUKAMGL-UHFFFAOYSA-N
Smiles	Cl.Cl.CCN(CC)CC1CCN(CC1)C1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BIBU 1361 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BIBU 1361 dihydrochloride

参考文献是支持产品生物活性的出版物。

Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID: 15199094

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