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BIBX 1382 dihydrochloride

Cat. No. 2416 1 次引用 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2416 has been discontinued.

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说明： Highly selective EGFR-kinase inhibitor
化学名： N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论 (2)
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for BIBX 1382 dihydrochloride

BIBX 1382 dihydrochloride is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.

技术数据 for BIBX 1382 dihydrochloride

分子量 460.77
公式 C18H19ClFN7.2HCl
储存 Desiccate at +4°C
纯度 ≥97% (HPLC)
CAS Number 1216920-18-1
PubChem ID 46861540
InChI Key RFXGEKWBTCMDAW-UHFFFAOYSA-N
Smiles Cl.Cl.CN1CCC(CC1)NC1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BIBX 1382 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BIBX 1382 dihydrochloride

参考文献是支持产品生物活性的出版物。

Dittrich et al (2002) Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur.J.Cancer 38 1072 PMID: 12008195

Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID: 15199094

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关键词: BIBX 1382 dihydrochloride, BIBX 1382 dihydrochloride supplier, selective, EGFR-kinases, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, BIBX1382, dihydrochloride, EGFR, 2416, Tocris Bioscience

1 篇 BIBX 1382 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIBX 1382 dihydrochloride 的部分引用包括：

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643

BIBX 1382 dihydrochloride 的评论

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Blockage of EGFR signaling.
By MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human

BIBX 1382 dihydrochloride was used to block EGFR signaling and determine the pathway of a chemotherapeutic in glioblastoma lines. The inhibitor worked nicely, and the results were consistent.

In vitro culture.
By Anonymous on 08/05/2018
分析类型： In Vitro
种属： Mouse

Used in vitro to investigate ERG pathways

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