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Submit ReviewBicalutamide
说明： Non-steroidal androgen receptor antagonist
别名： Casodex,ICI 176,334
化学名： N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
纯度： ≥99% (HPLC)
生物活性 for Bicalutamide
Bicalutamide is an orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.
许可信息
Sold for research purposes only under agreement from AstraZeneca
化合物库 for Bicalutamide
Bicalutamide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Bicalutamide
| 分子量 | 430.37 |
| 公式 | C18H14F4N2O4S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 90357-06-5 |
| PubChem ID | 2375 |
| InChI Key | LKJPYSCBVHEWIU-UHFFFAOYSA-N |
| Smiles | O=C(C(O)(C)CS(C2=CC=C(F)C=C2)(=O)=O)NC1=CC(C(F)(F)F)=C(C#N)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Bicalutamide
参考文献 for Bicalutamide
参考文献是支持产品生物活性的出版物。
Furr et al (1987) ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J.Endocrinol. 113 R7 PMID: 3625091
Tucker et al (1988) Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. J.Med.Chem. 31 954 PMID: 3361581
Furr and Tucker (1996) The preclinical development of bicalutamide: pharmacodynamics and mechanism of action. Urology 47 13 PMID: 8560673
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关键词: Bicalutamide, Bicalutamide supplier, Non-steroidal, Androgen, receptor, antagonists, Dihydrotestosterone, Receptors, AstraZeneca, ICI176,334, chemotherapeutics, Casodex, ICI, 176,334, Receptor, 3389, Tocris Bioscience
4 篇 Bicalutamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Bicalutamide 的部分引用包括：
Olokpa et al (2016) The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells. J Cell Physiol 231 2664 PMID: 26945682
Gambara et al (2015) TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo. J Cell Mol Med 19 327 PMID: 25444175
Ivachtchenko et al (2014) Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment. PLoS One 5 133 PMID: 24494031
Ishizaki et al (2013) Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Sci Rep 3 1528 PMID: 23524847
Bicalutamide 的评论
平均评分: 5 (Based on 1 Review.)
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In vitro culture with c4-2 cells to induce AR reduction.
By
Anonymous on 11/03/2019
分析类型： In Vitro
种属： Human
细胞系/组织： c4-2 cell
in vitro culture with c4-2 cells to induce AR reduction
