Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBigLEN (mouse)
说明： GPR171 agonist
纯度： ≥95% (HPLC)
生物活性 for BigLEN (mouse)
BigLEN (mouse) is a GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.
技术数据 for BigLEN (mouse)
| 分子量 | 1756.03 |
| 公式 | C78H130N24O22 |
| 序列 | LENPSPQAPARRLLPP |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 501036-69-7 |
| PubChem ID | 131648250 |
| InChI Key | UEWHHQZTIIRRRA-REWHPCPNSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BigLEN (mouse)
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for BigLEN (mouse)
参考文献 for BigLEN (mouse)
参考文献是支持产品生物活性的出版物。
Wardman et al (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One 6 e28152 PMID: 22164236
Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 10 1884 PMID: 30726666
If you know of a relevant reference for BigLEN (mouse), please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: BigLEN (mouse), BigLEN (mouse) supplier, GPR171, agonists, agonism, neuropeptide, proSAAS, food, intake, glutamate, release, parvocellular, neurons, 6304, Tocris Bioscience
1 篇 BigLEN (mouse) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BigLEN (mouse) 的部分引用包括：
Richard D et al (2021) The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun 12 5857 PMID: 34615877
您是否知道使用了 Tocris BigLEN (mouse) 的优秀论文？ 请告知我们.
BigLEN (mouse) 的评论
平均评分: 5 (Based on 1 Review.)
Have you used BigLEN (mouse)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Test.
By
Jacob Painter on 07/07/2022
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Lymphoid Cells
I used this to screen for the activation of cell activity. I found the ideal concentrations to be around 1 - 25 uM to be ideal for my needs. It performed as expected and was easy to reconstitute. It stored at 2 mg/mL at -20C for more than 3months.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.