BIIB 021

Discontinued Product

4608 has been discontinued.

View all Hsp90 products.
说明: Selective Hsp90 inhibitor
别名: CNF 2024
化学名: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)

生物活性 for BIIB 021

BIIB 021 is a selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

技术数据 for BIIB 021

分子量 318.76
公式 C14H15ClN6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 848695-25-0
PubChem ID 16736529
InChI Key QULDDKSCVCJTPV-UHFFFAOYSA-N
Smiles ClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BIIB 021

参考文献是支持产品生物活性的出版物。

Lundgren et al (2009) BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol.Cancer Ther. 8 921 PMID: 19372565

Yin et al (2010) BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int.J.Cancer 126 1216 PMID: 19662650

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关键词: BIIB 021, BIIB 021 supplier, BIIB021, heat, shock, proteins, 90, hsp90, inhibitors, chaperones, HER-2, antitumor, antitumour, CNF2024, inhibits, orally, bioavailable, potent, selective, CNF, 2024, Hsp90, 4608, Tocris Bioscience

1 篇 BIIB 021 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIIB 021 的部分引用包括:

Catherine B et al (2021) Inhibition of the NLRP3 inflammasome by HSP90 inhibitors. Immunology 162 84-91 PMID: 32954500


BIIB 021 的评论

平均评分: 5 (Based on 1 Review.)

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BIIB 021 induces PARP cleavage in U2OS cells.
By Anonymous on 03/25/2019
分析类型: In Vitro
种属: Human
细胞系/组织: Osteosarcoma

Human osteosarcoma, U2OS, cells were treated with BIIB 021 (1 microM) for 24 h to follow PARP cleavage using Western blot. BIIB 021 activated PARP cleavage in U2OS cells

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